2000 Taplin Award, Division of Health Sciences and Technology, Harvard Medical School/MIT
2002 Clifford Barger Mentor Award, Harvard Medical School
Isaac (Zak) Kohane is the director of the Children's Hospital Informatics Program and is the Henderson Associate Professor of Pediatrics and Health Sciences and Technology at Harvard Medical School (HMS). He is also co-director of the HMS Center for Biomedical Informatics and Director of the HMS Countway Library of Medicine. Dr. Kohane leads multiple collaborations at Harvard Medical School and its hospital affiliates in the use of genomics and computer science to study cancer and the development of the brain (with emphasis on autism). He has developed several computer systems to allow multiple hospital systems to be used as "living laboratories" to study the genetic basis of disease while preserving patient privacy. Dr. Kohane's research builds on his doctoral work in computer science on decision-support and subsequent research in machine-learning applied to biomedicine. Dr. Kohane has led the development of cryptographic health identification systems, automated personal health records and peer-to-peer pathology information networks. Dr. Kohane leads several NIH-funded efforts to translate genomic research into clinical practice and continues his own practice in pediatric endocrinology at Children's Hospital.
Butte AJ, Tamayo P, Slonim D, Golub TR, Kohane IS. Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks. Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12182-6.
Kho AT, Zhao Q, Cai Z, Butte AJ, Kim JY, Pomeroy SL, et al. Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev. 2004 Mar 15;18(6):629-40.
Butte AJ, Kohane IS. Creation and implications of a phenome-genome network. Nat Biotechnol. 2006 Jan;24(1):55-62.
Liu H, Kho AT, Kohane IS, Sun Y. Predicting Survival within the Lung Cancer Histopathological Hierarchy Using a Multi-Scale Genomic Model of Development. PLoS Med. 2006 Jul 4;3(7):e232.
Inaoka H, Fukuoka Y, Kohane IS. Evidence of spatially bound gene regulation in Mus musculus: decreased gene expression proximal to microRNA genomic location. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5020-5.
Kohane IS, Mandl KD, Taylor PL, Holm IA, Nigrin DJ, Kunkel LM. Medicine. Reestablishing the researcher-patient compact. Science. 2007 May 11;316(5826):836-7.