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Dr. Bonventre studies the mechanisms of cellular and tissue injury and repair, particularly as applied to ischemic injury to the kidney (ischemic acute renal failure, ARF). One of the major focus of his laboratory studies is the phospholipase A2(PLA2) and the role of this family of enzymes on acute tissue injury, apoptosis, signal transduction and nuclear events including transcription. By understanding the role that PLA2s play in injury, Dr. Bonventre and his colleagues will have better insights into the mechanisms that are important for gene regulation such as cell proliferation, cell death and tissue repair after acute renal failure.
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