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Our main interests are the genetic and enzymatic regulation of B cell development, and the role of B cell signaling in autoimmunity and lymphomagenesis. Currently we focus on two enzymes- a sialic acid acetylesterase that negatively regulates B cell signaling and is frequently mutated in patients with autoimmunity, and a sialic acid acetyltransferase that is a positive regulator of B cell activation and is a target for the treatment of autoimmune disorders. We are also interested in B cell subsets, the regulation of the humoral immune response and in identifying the cells of origin of B lymphoid malignancies.
77 Massachusetts Avenue, E25-519, Cambridge, MA 02139